| 发明名称 |
Bicyclic carboxylic acids and their derivatives asnep and aca inhibitors. |
| 摘要 |
<p>Compounds of the formula <CHEM> wherein X is O or S-(O)t; n is one or two; m is zero or one; Y is CH2, O, or S-(O)t provided that Y is O or S-(O)t only when m is one; and A is <CHEM> are dual inhibitors of NEP and ACE. Compounds wherein A is <CHEM> are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.</p> |
| 申请公布号 |
HK1001814(A1) |
申请公布日期 |
2005.01.14 |
| 申请号 |
HK19980100738 |
申请日期 |
1998.01.27 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
ROBL, JEFFREY, A.;KRONENTHAL, DAVID, R.;GODEREY, JOLLIE, D., JR. |
| 分类号 |
A61K31/535;A61K31/5365;A61K31/5383;A61K31/54;A61K31/542;A61K31/55;A61K31/553;A61K31/554;A61K38/00;A61P9/04;A61P9/12;A61P43/00;C07C315/02;C07C317/50;C07C319/14;C07C319/20;C07C323/59;C07C327/34;C07D;C07D498/04;C07D513/04;C07K5/078;(IPC1-7):C07D;C07C;A61K |
主分类号 |
A61K31/535 |
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