发明名称 |
Process for preparing (R) salbutamol |
摘要 |
The present invention relates to an improved process for preparing levosalbutamol or the pharmacologically acceptable salts thereof on an industrial scale, using asymmetric hydrogenation as the key step and optionally a special sequence of subsequent steps, using rhodium as catalyst and a chiral bidentate phosphine ligand such as (2R, 4R)-4-(dicyclohexylphosphino)-2-(diphenyl-phosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine as catalyst system.
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申请公布号 |
US2005009926(A1) |
申请公布日期 |
2005.01.13 |
申请号 |
US20030692060 |
申请日期 |
2003.10.23 |
申请人 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG |
发明人 |
KREYE PAUL;LENHART ALFONS;KLINGLER FRANZ DIETRICH |
分类号 |
C07C213/00;C07C215/60;(IPC1-7):A61K31/137;C07C215/46 |
主分类号 |
C07C213/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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