METHODS AND COMPOSITIONS FOR THE TARGETING OF A SYSTEMIC IMMUNE RESPONSE TO SPECIFIC ORGANS OR TISSUES

摘要

The invention provides methods and compositions for targeting a separately generated immune response to a specific organ or tissue; e.g. one affected by cancer, using one or more agents with a tropism for the organ or tissue r that can be specifically localized to the desired organ or tissue. For example, the invention provides methods and compositions for treating liver metastases from colorectal cancer using a combination of a granulocyte/macrophage colony stimulating factor (GM-CSF) augmented tumor cell vaccination and Listeria monocytogenes (LM) infection.