摘要 |
An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula I:wherein R<1 >is selected from: H, haloalkyl, (C1-6)alkyl, (C2-6)alkenyl, (C3-7)cycloalkyl, (C2-6)alkynyl, (C5-7)cycloalkenyl, 6 or 10-membered aryl, Het all optionally substituted;R<2 >is selected from (C1-6)alkyl, (C3-7)cycloalkyl, (C6-10)bicycloalkyl, 6- or 10-membered aryl, or Het all optionally substituted;B is N or CR<5>, wherein R<5 >is H, halogen, haloalkyl, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; X is N or CR<5>; D is N or CR<5>; each of Y1 and Y2 is independently O or S; Z is O, N, or NR<Z >wherein R<Z >is H, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; R<3 >and R<4 >are each independently H, (C1-6)alkyl, first (C3-7)cycloalkyl or 6- or 10-membered aryl, Het (C1-6)alkyl-6- or 10-membered aryl, (C1-6)alkyl-Het; or each R<3 >and R<4 >are independently covalently bonded together to form second (C3-7)cycloalkyl, or heterocycle, all optionally substituted; or when Z is N, either R<3 >or R<4 >are independently covalently bonded thereto to form a nitrogen-containing heterocycle; R<7 >is H, (C1-6alkyl), (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; or R<7 >is covalently bonded to either of R<3 >or R<4 >to form a heterocycle; A is (C1-6)alkyl-CONHR<8 >wherein R<8 >is -6- or 10-membered aryl, or Het; or A is a 6- or 10-membered aryl, or Het said aryl or Het being optionally substituted; or a salt or a derivative thereof; such compounds being potent inhibitors of HCV NS5B polymerase.
|