发明名称 |
Herpes virus complementing cell line |
摘要 |
The present invention is directed to a cell line capable of supporting replication of a growth-defective Herpes Simplex Virus strain; specifically a replication-defective HSV-2 double mutant. Particularly disclosed is a cell line that expresses the ICP8 protein and the UL5 protein of Herpes Simplex Virus. This cell line is useful to propagate a replication-defective HSV-2 vaccine strain that contains mutations and/or deletions in the ICP8 and UL5 genes.
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申请公布号 |
US6841373(B2) |
申请公布日期 |
2005.01.11 |
申请号 |
US20020257229 |
申请日期 |
2002.10.10 |
申请人 |
AVANT IMMUNOTHERAPEUTICS, INC. |
发明人 |
METCALFE KAREN |
分类号 |
A61K39/245;A61P31/22;C07K14/035;C12N5/10;C12N7/01;C12N7/04;(IPC1-7):C12N5/10 |
主分类号 |
A61K39/245 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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