发明名称 |
TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES BY ANTIBODIES AGAINST GLATIRAMER ACETATE |
摘要 |
The present invention provides humanized polyclonal and humanized monoclonal antibodies directed against an epitope on glatiramer acetate, also known as Copolymer 1, Copolymer-1, Cop-1 or Cop. Additionally, the subject invention concerns a pharmaceutical composition comprising an antibody directed against an epitope on glatiramer acetate for the treatment of a disease associated with demyelination of central nervous system axons. Also encompassed by the subject invention is a method of treating a subject suffering from a disease associated with demyelination of central nervous system axons. The subject invention further contains methods of stimulating remyelination of central nervous system axons. In addition, the subject invention provides a method of stimulating proliferation of lymphocytes. |
申请公布号 |
PL365458(A1) |
申请公布日期 |
2005.01.10 |
申请号 |
PL20010365458 |
申请日期 |
2001.06.20 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES,LTD. |
发明人 |
RODRIGUEZ MOSES;URE DAREN |
分类号 |
G01N33/53;A61K31/785;A61K38/16;A61K39/395;A61P3/00;A61P25/00;C07K16/18;C07K16/44;C12N5/02;C12P21/08;G01N33/577 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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