POLY-GAMMA-GLUTAMIC CONJUGATES FOR ELICITING IMMUNE RESPONSES DIRECTED AGAINST BACILLI

摘要

Immunogenic compositions and methods for eliciting an immune response agains t B. anthracis and other bacilli are provided that include immunogenic conjugates of a poly-.gamma.-glutamic acid (.gamma.PGA) polypeptides of B. anthracis, or of another Bacillus that expresses a .gamma.PGA polypeptide. T he .gamma.PGA conjugates elicit an effective immune response against B. anthracis, or against another Bacillus, in mammalian hosts to which the conjugates are administered. The preferred conjugate consists of .gamma.-D-P GA and Bacillus protective antigen.