Method for identifying fungicides using guanylate kinase

摘要

Identifying fungicides (I) by contacting a fungal polypeptide (I) having guanylate kinase (GK) activity with one or more chemicals; comparing GK activity in presence and absence of test compounds, then selecting compounds that inhibit GK specifically, is new. Independent claims are also included for: (1) use of inhibitors (II) of GK as fungicides; (2) nucleic acid (NA) that encodes (I) from phytopathogenic fungi; (3) DNA construct that contains NA and a heterologous promoter; (4) vector that contains NA or the construct of (3); (5) host cell that contains NA, the construct of (3) or the vector of (4); and (6) polypeptides with GK activity encoded by NA. ACTIVITY : Plant Antifungal; Fungicide. No biological data given. MECHANISM OF ACTION : Inhibition of guanylate kinase.