发明名称 |
Efficient inhibition of hiv-1 viral entry through a novel fusion protein including of cd4 |
摘要 |
Novel recombinant polypeptides are disclosed herein that include a CD4 polypeptide ligated at its C-terminus with a portion of an immunoglobulin comprising a hinge region and a constant domain of a mammalian immunoglobulin heavy chain. The portion of the IgG is fused at its C-terminus with a polypeptide comprising a tailpiece from the C-terminus of the heavy chain of an IgA antibody or a tailpiece from a C-terminus of the heavy chain of an IgM antibody. Also disclosed herein are methods for using these CD4-fusion proteins.
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申请公布号 |
US2004265306(A1) |
申请公布日期 |
2004.12.30 |
申请号 |
US20040493676 |
申请日期 |
2004.07.27 |
申请人 |
ARTHOS JAMES;CICALA CLAUDIA;FAUCI ANTHONY S. |
发明人 |
ARTHOS JAMES;CICALA CLAUDIA;FAUCI ANTHONY S. |
分类号 |
A61K38/00;C07K14/73;C12P21/08;(IPC1-7):A61K39/395;C07K16/28 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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