发明名称 |
Methods of treating disorders related to apoE |
摘要 |
The present invention provides methods inhibiting formation of neurofibrillary tangles; and methods for treating disorders relating to apolipoprotein E (apoE) in a subject. The methods generally involve reducing the level of a carboxyl-terminal truncated form of apoE in a neuronal cell of a subject. The invention further provides isolated cells comprising a nucleic acid molecule encoding a carboxyl-terminal truncated form of apoE; and methods of screening compounds using the cells. The invention further provides compounds that inhibit an apoE cleavage enzyme, and that reduce the formation of neurofibrillary tangles in a neuronal cell. The invention further provides transgenic non-human animals that include as a transgene a nucleic acid that encodes a carboxyl-terminal truncated form of apoE; as well as methods of screening compounds using transgenic animals.
|
申请公布号 |
US2004268423(A1) |
申请公布日期 |
2004.12.30 |
申请号 |
US20040820618 |
申请日期 |
2004.04.07 |
申请人 |
HUANG YADONG;MAHLEY ROBERT W. |
发明人 |
HUANG YADONG;MAHLEY ROBERT W. |
分类号 |
A01K67/027;A61K38/00;A61K38/55;A61K45/00;A61P9/00;A61P9/10;A61P25/28;C07K5/103;C07K14/775;C12N5/06;C12N5/10;C12N15/09;C12Q1/02;C12Q1/37;G01N33/15;G01N33/50;G01N33/53;G01N33/566;(IPC1-7):A01K67/027;A61K38/17 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|