发明名称 |
Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors |
摘要 |
The present invention relates to gene therapy for the treatment of tumors. The invention more particularly relates to introduction of a gene encoding an anti-angiogenic factor into cells of a tumor, for example with a defective adenovirus vector, to inhibit growth or metastasis, or both, of the tumor. In a specific embodiment, delivery of a defective adenovirus that expresses the amino terminal fragment of urokinase (ATF) inhibited growth and metastasis of tumors. These effects were correlated with a remarkable inhibition of neovascularization within, and at the immediate vicinity of, the injection site. Delivery of a defective adenovirus vector that expresses kringles 1 to 3 of angiostatin inhibited tumor growth and tumorigenicity, and induced apoptosis of tumor cells. The invention further provides viral vectors for use in the methods of the invention.
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申请公布号 |
US2004265273(A1) |
申请公布日期 |
2004.12.30 |
申请号 |
US20030693688 |
申请日期 |
2003.10.27 |
申请人 |
LI HONG;LU HE;GRISCELLI FRANK;OPOLON PAULE;SORIA CLAUDINE;RAGOT THIERRY;LEGRAND YVES;SORIA JEANNETTE;MABILAT CHRISTELLE;PERRICAUDET MICHEL;YEH PATRICE |
发明人 |
LI HONG;LU HE;GRISCELLI FRANK;OPOLON PAULE;SORIA CLAUDINE;RAGOT THIERRY;LEGRAND YVES;SORIA JEANNETTE;MABILAT CHRISTELLE;PERRICAUDET MICHEL;YEH PATRICE |
分类号 |
C12N15/00;A61K35/76;A61K38/46;A61K38/48;A61K38/49;A61K48/00;A61P35/00;A61P35/04;C07K14/47;C12N15/57;(IPC1-7):A61K48/00;C12N15/86 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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