GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

摘要

Compounds of formula (I), salts, solvates and physiologically functional derivatives thereof are provided: formula (I) wherein R<1> and R<2> is independently selected from hydrogen, optionally substituted C1-6alkyl, optionally substituted C3-6cycloalkyl, optionally substituted aryl, optionally substituted arylC1-4alkyl and optionally substituted arylC3-6cycloalkyl, wherein R<1> and R<2> are not both hydrogen, or R<1> and R<2>, together with the nitrogen atom to which they are attached, are linked to form an optionally substituted 4-, 5-, 6- or 7-membered saturated ring, wherein one or more of the carbon atoms is optionally replaced by a heteroatom independently selected from N, O and S; R<3> is an optionally substituted group of formula (a): wherein m and n are independently 0, 1, 2 or 3 and m+n is 2, 3 or 4; each Z is independently -CH2-, -NH-, -O- or -S-; and each Y is independently CH or N; R<4> and R<5> are independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C6 cycloalkyl, optionally substituted aryl and optionally substituted arylC1-C4 alkyl; and R<6>, R<7>, R<8> and R<9> are independently selected from hydrogen, optionally substituted C1-C6 alkyl and optionally substituted arylC1-C4 alkyl, or R<6> and R<7> together form an optionally substituted C3-C6 cycloalkyl group, or R<8 >and R<9> together form an optionally substituted C3-C6 cycloalkyl group. Methods of preparation and uses of the compounds in medicine for the treatment of a disorder mediated by GlyT1, for example schizophrenia, are also disclosed.