发明名称 |
TRICYCLIC DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
摘要 |
The present invention relates to tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. More precisely, the present invention relates to tricyclic derivatives as colchicine derivatives, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. Tricyclic derivatives of the present invention show very powerful cytotoxici ty to cancer cell lines but were much less toxic than colchicine or taxol, confirmed through animal toxicity test. Tricyclic derivatives of the inventi on also decrease the volume and weight of a tumor and have a strong angiogenesi s inhibiting activity in HUVEC cells. Thus, tricyclic derivatives of the prese nt invention can effectively be used as an anticancer agent, anti-proliferation agent and an angiogenesis inhibitor.
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申请公布号 |
CA2531543(A1) |
申请公布日期 |
2004.12.29 |
申请号 |
CA20042531543 |
申请日期 |
2004.06.23 |
申请人 |
JE IL PHARMACEUTICALS CO., LTD. |
发明人 |
CHOI, JAE-WON;CHUN, KWANGWOO;PARK, SANG-WOO;JOE, BO-YOUNG;KIM, KWANG HEE;KIM, MYUNG-HWA;OH, BYUNG-KYU;CHOI, JONG-HEE |
分类号 |
C07C317/30;C07C323/41;C07C381/00;C07D213/81;C07D213/82;C07D307/68;C07D333/38 |
主分类号 |
C07C317/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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