| 摘要 |
The present invention provides a method for the treatment of the complicatio ns and pathology of diabetes. The method involves the administration to a diabetic subject of a composition comprisin g a compound selected from the group consisting of (.beta.-Ala-His)n, (Lys-His)n, a compound of the formula R1-X-R2, pharmaceutically acceptable salts thereof and combinations thereof; and a pharmaceutically acceptable carrier, in which n is 2-5, R1 is one or two naturally occurring amino acids, optionally alpha-amino acetylated with alkyl or aralkyl of 1 to 12 carbon atoms, preferably 2 to 6 carbon atoms, R2 is 1 or 2 naturally occurring amino acids, optionally alpha-carboxyl esterified or amidated with alkyl or aralkyl of 1 to 12 carbon atoms, preferably 2 to 6 carbon atoms and X is R3-L or D-His (R4)-R5 where R 3 is void or .omega.-aminoacyl with 1 to 12 carbon atoms, preferably 2 to 6 carbon atoms, R4 is void or imidazole modification with alkyl-sulphydryl, hydroxyl, halogen and/or amino groups; and R5 is void or carbonyl (alkyl) amides with 1 to 12 carbon atoms, preferably 2 to 6 carbon atoms. Preferably, the compound is carnosine.
|
