发明名称 |
FORMULATION AND USE OF CAROTENOIDS IN TREATMENT OF CANCER |
摘要 |
A reduced-toxicity formulation of carotenoids is disclosed which is stable i n an aqueous environment. The formulation includes a carotenoid, lipid carrier particles (such as liposomes), and an intercalation promoter agent (such as a triglyceride), which causes the carotenoid to be substantially uniformly distributed with the lip id in the lipid carrier particles. The molar ratio of carotenoid to lipid is greater than about 1:10. Also disclosed is a method o f inhibiting the growth of cancer cells, which comprises administering to a living subject a therapeutically effective amount of a composition as described above.
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申请公布号 |
CA2128103(C) |
申请公布日期 |
2004.12.28 |
申请号 |
CA19932128103 |
申请日期 |
1993.01.13 |
申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS;ARGUS PHARMACEUTICALS, INC. |
发明人 |
MEHTA, KAPIL;PEREZ-SOLER, ROMAN;LOPEZ-BERESTEIN, GABRIEL;LENK, ROBERT P.;HAYMAN, ALAN C. |
分类号 |
A61K9/127;A61K31/07;A61K31/11;A61K31/19;A61K31/20;A61K31/203;A61K31/215;A61K31/216;A61K47/10;A61K47/12;A61K47/14;A61K47/24;A61K47/32;A61P35/00;A61P35/02;A61P43/00;(IPC1-7):A61K31/20 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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