| 摘要 |
FIELD: organic chemistry, medicine, endocrinology, pharmacy. ^ SUBSTANCE: invention relates to new derivatives and analogues of 3-arylpropionic acid of the general formula (I) , ^ their seteroisomers, optical isomers and racemates and to their pharmaceutically acceptable salts. The group A in the indicated formula (I) is at meta- or para-position and it represents ^ wherein R represents hydrogen atom; -ORa wherein Ra represents hydrogen atom, alkyl, phenyl or alkylphenyl; -NRaRb wherein Ra and Rb are similar or different and represent hydrogen atom, alkyl, phenyl, alkylphenyl, cyano-group; R1 represents alkyl, cyano-group; -ORe wherein Re represents alkyl, phenyl or alkylphenyl; -O-[CH2]m-ORf wherein Rf represents alkyl; m represents a whole number 1-2; -SRd wherein Rd represents alkyl or phenyl; -SO2ORa wherein Ra represents alkyl, phenyl or alkylphenyl; -COORd wherein Rd represents alkyl; R2 represents hydrogen atom or alkyl; R3 and R4 are similar or different and each represents hydrogen atom or alkyl; n represents a whole number 1-3; D is at ortho-, meta- or position and represents -OSO2Rd wherein Rd represents alkyl, phenyl or alkylphenyl; -OCONRfRa wherein Rf and Ra represent hydrogen atom, alkyl, phenyl or alkylphenyl; -NRcCOORd wherein Rc represents hydrogen atom or alkyl, and Rd represents alkyl, phenyl or alkylphenyl; -NRcCORa wherein Rc represents hydrogen atom or alkyl, and Ra represents hydrogen atom, alkyl, phenyl or alkylphenyl; -NRcRd wherein Rc and Rd represent hydrogen atom, alkyl, phenyl or alkylphenyl; -NRcSO2Rd wherein Rc represents hydrogen atom or alkyl, and Rd represents alkyl, phenyl or alkylphenyl; -NRcCONRaRk wherein Rc represents hydrogen atom, Ra and Rk are similar or different and each represents hydrogen atom, alkyl, phenyl or alkylphenyl; -NRcCSNRaRk wherein Rc represents hydrogen atom, Ra and Rk are similar or different and each represents hydrogen atom, phenyl or alkylphenyl; -SO2Rd wherein Rd represents alkyl, phenyl or alkylphenyl; -SRc wherein Rc represents alkyl, phenyl or alkylphenyl; -SO2ORa wherein Ra represents alkyl, phenyl or alkylphenyl; -CN; -CONRcRa wherein Rc represents hydrogen atom or alkyl and Ra represents hydrogen atom or alkyl; D is at meta-position and represents -ORf wherein Rf represents alkyl, or it represents hydrogen atom; D'' is at ortho-, meta- or para-position and represents hydrogen atom wherein indicated alkyl a direct or branched alkyl group comprising from 1 to 6 carbon atoms, either cyclic alkyl comprising from 3 to 6 carbon atoms being indicated alkyl can be substituted with one or more group taken among alkyl, alkoxy-, halogen atom or phenyl wherein indicated phenyl can be substituted with one or more group taken among alkyl, alkoxy-, nitro-, thiol or halogen atom. Also, invention relates to a method for their preparing, pharmaceutical preparations comprising thereof and applying these compounds in clinical states associated with resistance to insulin. ^ EFFECT: valuable medicinal properties of compounds. ^ 41 cl, 109 ex |
