BENZAMIDE DERIVATIVE OR SALT THEREOF

摘要

A compound which functions to inhibit capsaicin receptor VR1 activation and is useful as a therapeutic agent for, e.g., various pains including inflammator y pain and neurogenic pain, migraine, cluster headache, and bladder diseases including overactive bladder. It is a benzamide derivative or salt thereof, the derivative being characterized by comprising: a benzene ring; a ring D ( a mono- or dicyclic hydrocarbon ring or mono- or dicyclic heteroaromatic ring) bonded to the benzene ring through an amide bond; a ring E (a mono- or dicyclic hydrocarbon ring or mono- or dicyclic heteroaromatic ring) directly bonded to the benzene ring; and A (an amino moiety or a mono- or dicyclic heteroring) bonded to the benzene ring through L (a lower alkylene).