VASCULAR ENDOTHELIAL GROWTH FACTOR FUSION CONSTRUCTS AND USES THEREOF

摘要

The 121-amino acid isoform of vascular endothelial growth factor (VEGF121) i s linked by a flexible G4S tether to a cytotoxic molecule such as toxin geloni n or granzyme B and expressed as a soluble fusion protein. The VEGF121 fusion protein exhibits significant anti-tumor vascular-ablative effects that inhib it the growth of primary tumors and inhibit metastatic spread and vascularizati on of metastases. The VEGF121 fusion protein may also target osteoclast precurs or cells in vivo and inhibits osteoclastogenesis.