发明名称 |
FLUORO-ALKYL-CYCLOPEPTIDE DERIVATIVES HAVING ANTI-INTEGRIN ACTIVITY |
摘要 |
Compounds of formula (I) cyclo [NX1-R1-CO-NX2-R2-CO-NX3-R3-CO-NX4-CO-NX5-R5-CO], wherein at least one x-fluoroalkylated amino acid is present, are inhibitors of integrins, particularly those belonging to the alphavbeta3 and alphavbeta5 family, and thus are useful as medicaments, particularly for the treatment of the underlying diseases responsible for abnormal angiogenesis, such as retinopathy, acute kidney failure, osteoporosis and metastases. The compounds described herein are also useful as diagnostic agents, when appropriately labelled, especially for the detection and location of small tumour masses and arterial occlusion events.
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申请公布号 |
WO2004011487(A8) |
申请公布日期 |
2004.12.16 |
申请号 |
WO2003IT00446 |
申请日期 |
2003.07.18 |
申请人 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.;DAL POZZO, ALMA;GIANNINI, GIUSEPPE;PISANO, CLAUDIO |
发明人 |
DAL POZZO, ALMA;GIANNINI, GIUSEPPE;PISANO, CLAUDIO |
分类号 |
A61K38/00;C07K7/54;C07K7/64;(IPC1-7):C07K7/54;A61K38/12;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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