发明名称 N3 ALKYLATED DERIVATIVES OF BENZIMIDAZOLE AS MEK INHIBITORS
摘要 Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein W, t, R1, R2, R7, R9, R10, R11 and R12 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds. (I)
申请公布号 UA76837(C2) 申请公布日期 2004.12.15
申请号 UA20040907721 申请日期 2003.03.13
申请人 ARRAY BIOPHARMA, INC. 发明人 WALLACE ELI M;LYSSIKATOS JOSEPH P;HURLEY BRIAN;MARLOW ALLISON L
分类号 C07D235/08;A61K31/4184;A61K31/443;A61K31/4439;A61K31/537;A61K31/5377;A61P35/00;C07D235/06;C07D401/04;C07D401/06;C07D403/06 主分类号 C07D235/08
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