ANGIOGENIN-BASED HIV-1 THERAPIES

摘要

Methods for treatment of highly mutating viruses and viruses which establish chronic or latent infections in an individual are provided. In particular, it is shown that angiogenin is a potent inhibitor of viral replication, such as HIV-1. This has several advantages over other known ribonucleases that are used to inhibit HIV-1 replication as angiogenin inhibits HIV-1 replication in primary activated T lymphocyte cultures as well as chronically infected cell lines. Inhibition of HIV-1 replication in primary activated T lymphocytes would decrease the risk of HIV spreading to other susceptible cells.