METHOD OF DETERMINING EFFICACY OF ANTICANCER DRUG AND DETERMINATION KIT THEREFOR

摘要

A method of determining the efficacy of anticancer drug whereby accurate determination can be realized; and a determination kit therefor. In the determination of the efficacy of anticancer drugs, especially a tyrosine kinase inhibitor, Jab1 protein is used as an index of determination and the form of existence of Jab1 protein is checked. As the form of existence there can be mentioned Jab1 small complex of 120 kDa molecular weight, and the typ e having sensitivity to the efficacy of anticancer drug can be accurately determined by checking the expression of p27 protein.