<p>A method for processing two or more liquid aliquots in a microchannnel structure of a microfluidic device. The microchannel structure comprises a hydrophilic microconduit with a fluidic function and a local non-wettable surface associated with the fluidic function/microconduit. The characterizing features are: A) said processing comprises the steps of: i) passing a liquid aliquot I that contains components selected amongst organic solvents and surface active entities through the microconduit, and ii) passing another liquid aliquot II through the microconduit, and B) said non-wettable local surface area exposes fluoro groups on its surface and/or a rough part. A method for producing the fluidic function defined above. The method comprises introducing non-wettability on a local surface area S that is associated with the microconduit. The method comprises the steps of: i) providing said local surface S; ii) contacting this surface with a fixatable fluoropolymer; and iii) fixating the fluoropolymer to this surface. The fluidic function is typically selected amongst passive valves, anti-wicking functions, vents and liquid-directing functions.</p>
