发明名称 |
Recombinant influenza viruses with bicistronic vRNAs coding for two genes in tandem arrangement |
摘要 |
The invention relates to recombinant influenza viruses for high-yield expression of incorporated foreign gene(s), which are genetically stable in the absence of any helper virus and which comprise at least one viral RNA segment being a tandem bicistronic RNA molecule coding for two genes in tandem, in said tandem bicistronic RNA molecule one of the standard viral genes being in covalent junction with a foreign, recombinant gene and having an upstream splice donor and a downstream splice acceptor signal surrounding the proximal coding region. The invention further provides a method for obtaining attenuated viruses which resist reassortment dependent progeny production in case of chance superinfections by wild-type influenza viruses; a method for the production of said recombinant influenza viruses; pharmaceutical compositions comprising said recombinant influenza viruses; and the use of said recombinant influenza viruses for preparing medicaments for vaccination purposes.
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申请公布号 |
US2004241139(A1) |
申请公布日期 |
2004.12.02 |
申请号 |
US20010909238 |
申请日期 |
2001.07.19 |
申请人 |
HOBOM GERD;MENKE ANNETTE;MEYER-ROGGE SABINE |
发明人 |
HOBOM GERD;MENKE ANNETTE;MEYER-ROGGE SABINE |
分类号 |
A61K48/00;C07K14/11;C12N7/04;C12N15/86;(IPC1-7):A61K48/00;C12N7/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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