发明名称 |
METHODS FOR INDUCING DIFFERENTIATION OF EMBRYONIC STEM CELLS AND USES THEREOF |
摘要 |
The present invention provides a method for inducing differentiation of an embryonic stem cell into a differentiated neural cell. The present invention further provides a method for producing differentiated neural cells, and a population of cells comprising the differentiated neural cells. Additionally, the present invention provides a method for repopulating a spinal cord in a subject, and a method for treating nervous tissue degeneration in a subject in need of treatment. The present invention further provides neural progenitor cells, differentiated neural cells, and uses of same. Also provided is a transgenic non-human animal containing the differentiated neural cells. The present invention is further directed to a method for isolating a population of differentiated neural cells. Finally, the present invention provides a method for identifying an agent for use in treating a condition associated with neuron degeneration. |
申请公布号 |
WO2004007665(A3) |
申请公布日期 |
2004.12.02 |
申请号 |
WO2003US20399 |
申请日期 |
2003.06.26 |
申请人 |
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEWYORK |
发明人 |
JESSEL, THOMAS, M.;WICHTERLE, HYNEK;LIEBERAM, IVO |
分类号 |
A61K35/12;C12N5/0793 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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