发明名称 |
MODULATORS OF THE P2Y10 RECEPTOR USEFUL IN ALTERING T LYMPHOCYTE FUNCTION |
摘要 |
The present invention relates to modulators of P2Y10. Various modulators are disclosed, including an antibody that binds specifically to P2Y10. The present invention also relates to methods of activating resting T lymphocytes and inhibiting the proliferation of activated T lymphocytes. Methods of upregulating trascription of P2Y10 mRNA in a resting T lymphocyte, methods of inducing expression of P2Y10 on the surface of a resting T lymphocyte and methods of activating a T lymphocyte are disclosed. Also disclosed are pharmaceuticals and methods of treating an immune disease. |
申请公布号 |
WO2004103293(A2) |
申请公布日期 |
2004.12.02 |
申请号 |
WO2004US15102 |
申请日期 |
2004.05.14 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;BURKE, JAMES, R.;IOTZOVA, VIOLETTA |
发明人 |
BURKE, JAMES, R.;IOTZOVA, VIOLETTA |
分类号 |
A01N37/18;A61K;A61K38/16;A61K39/00;A61K39/395;C07K16/00;C07K16/18;C12N5/00;C12N5/06;C12N5/16;C12P21/08;G01N33/50;G01N33/53 |
主分类号 |
A01N37/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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