Modified polypeptides for targeting cell-entry of the adenoviruses of subtype B

摘要

A modified polypeptide (I), comprising a polypeptide derived from extracellular domain of CD46, and a component capable of binding to a cell surface molecule, with the proviso that the component is not a polypeptide derived from CD55, is new. Independent claims are also included for: (1) nucleic acid (II) comprising a nucleic acid sequence encoding (I); (2) a recombinant expression vector (III) comprising (II) operably linked to at least one regulatory sequence for expression of (I); (3) host cell (IV) containing (II) or (III); (4) producing (I); and (5) a pharmaceutical composition (PC) comprising (I) and a carrier. ACTIVITY : Immunostimulant; CNS-Gen.; Respiratory-Gen.; Antiarthritic; Neuroprotective; Cytostatic. No biological data given. MECHANISM OF ACTION : None given.