发明名称 |
Labeled oligonucleotides, methods for making same, and compounds useful therefor |
摘要 |
Selectively functionalized oligonucleotides, methods for making same, and compounds useful therefor are disclosed. The oligonucleotides can be selectively functionalized with a first conjugate group at the 3'-terminial position and optionally functionalized with a second conjugate group at the 5'-terminal position and/or one or more internucleotides. Alternatively, the oligonucleotides can be selectively functionalized with a first conjugate group at the 5'-terminal position and optionally functionalized with a second conjugate group at one or more internucleotides. In yet another embodiment, the oligonucleotides can be functionalized with a first conjugate group at one or more internucleotides and with a second conjugate group at one or more different internucleotides.
|
申请公布号 |
US6825338(B2) |
申请公布日期 |
2004.11.30 |
申请号 |
US20010823031 |
申请日期 |
2001.03.30 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
MANOHARAN MUTHIAH;GUZAEV ANDREI P. |
分类号 |
C07H21/00;(IPC1-7):C07H21/00;C07H21/02;C07H21/04 |
主分类号 |
C07H21/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|