OLIGO-2'-DEOXYNUCLEOTIDES AND THEIR USE AS PHARMACEUTICAL AGENTS WITH ANTIVIRAL ACTIVITY

摘要

Oligodeoxyribonucleotides in which at least two 2'- deoxy-B-D-erythro-pentofuranosoyl groups are replaced by 2'-deoxy-B-D-threo-pentofuranosyl groups at both the 5' end and 3' end, and oligodeoxyribonucleotides in which at least 20 % of the 2'-deoxy-B-D-erythro-pentofuranosyl groups in consecutive nucleotide building blocks are replaced by 2'-deoxy-B-D-threo-pentofuranosyl groups and which are composed of 6 to 100 nucleotide building blocks, are suitable for the inhibition of the expression of viral genes and oncogenes by the antisense principle and can be used for the production of pharmaceutical agents with antiviral activity.