摘要 |
A method for the preparation of citalopram comprises reduction of a compound of formula (III) wherein X is a cyano group, or a group which can be converted to a cyano group, and where X is not a cyano group followed by the conversion of X to a cyano group, and isolation of citalopram in the form of the base or as a pharmaceutically acceptable acid addition salt thereof. Also described is the compound of formula (V) wherein X is a cyano group or a group which can be converted to a cyano group or an acid addition salt thereof and an antidepressant pharmaceutical composition comprising citalopram manufactured by the method described above.
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