| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for evaluating biofunctions by using the expression, decomposition or their change of a cancer suppressing gene RB1CC1 or its genetic product in vivo, especially in a cell or a tissue as an index. SOLUTION: Biofunctions can be evaluated by using the expression, decomposition or change of RB1CC1 as an index based on the findings that RB1CC1 is expressed even in a normal cell, other mRNA is expressed in a degenerated nerve cell in a nerve degenerative disease, the expression of RB1CC1 is lowered even in the early stage of the disease maintaining the cell form, and RB1CC1 is decreased from early stage in various kinds of culture cells when the cells are in lethal stage by a chemotherapeutic agent, etc. COPYRIGHT: (C)2005,JPO&NCIPI
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