| 摘要 |
A method and system for determining the sequence of nucleic-acid polymers that is particularly useful for identifying various combinations of subsequences of a longer nucleic-acid sequence. Positive probes, including tiling probes (1102), jump probes (1308), and exonic tiling probes (1202), are employed within a microarray, along with a number of different types of negative control probes, including deletion-negative-control probes, reverse-jump-negative-control probes (1708), exon-linker-negative-control probes (1804), and intron/exon-negative-control probes (1904). The different types of positive probes combined with the different types of negative control probes provide a more precise and less ambiguous determination of various subsequent combinations that, for example, result from post-transcriptional splicing of mRNA transcripts.. <IMAGE>
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