发明名称 |
Process for the manufacture of 7-amino-3-exomethylene-3-cepham-4-carboxylic acid ester |
摘要 |
A one-pot process for preparing 7-amino-3-exomethylene-3-cepham-4-carboxylic acid ester (II) comprises: (a) reacting 7-acylamino-3-exomethylene-3-cepham-1-oxide-4-carboxylic acid ester (I) with a silylating agent in an inert solvent and in the presence of a base, (b) adding a phosphorous halide to produce an iminohalide, and (c) adding an anhydrous alcohol. In a preferred embodiment, the silylating agent comprises trimethylchlorosilane, and the phosphorous halide comprises phosphorous pentachloride.
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申请公布号 |
US5159071(A) |
申请公布日期 |
1992.10.27 |
申请号 |
US19910696099 |
申请日期 |
1991.05.06 |
申请人 |
RANBAXY LABORATORIES LIMITED |
发明人 |
KHANNA, JAG M.;KUMAR, YATENDRA;HUSAIN, MASHKOOR |
分类号 |
C07D501/00;C07D501/04 |
主分类号 |
C07D501/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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