PROCESS TO INCREASE THE PRODUCTION OF CLAVAM ANTIBIOTICS
摘要
A process for increasing the amount of clavam produced by an organism having both a clavam pathway or a portion thereof and a cephalosporin pathway or a portion thereof by interfering with the conversion of L-lysine to L-alpha-aminoadipic acid in the cephalosporin pathway. Plasmids containing a defective LAT (lysine amino transferase) gene and organisms containing such plasmids are also provided.
申请公布号
EP0832247(B1)
申请公布日期
2004.11.24
申请号
EP19960921954
申请日期
1996.06.06
申请人
SMITHKLINE BEECHAM PLC;THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
发明人
HOLMS, WILLIAM, HENRY;PARADKAR, ASHISH SUDHAKAR;MOSHER, ROY HENRY;JENSEN, SUSAN E., DR.