INDOLE3PROPIONIC ACIDS, SALTS AND ESTERS THEREOF USED AS MEDICAMENTS.

摘要

The cytotoxic effects of amyloid beta protein on cells are prevented by contacting the cells with an effective amount of an indole3propionic acid or a salt or ester thereof. Furthermore, a fibrillogenic disease can be treated in a human subject by administering to the human subject an amount of an indole3propionic acid or a salt or ester thereof effective to prevent or reverse fibrillogenesis. Oxidation in a biological sample can be decreased by contacting the biological sample with an effective amount of an indole3propionic acid or a salt or ester thereof. Additionally, diseases or other conditions where free radicals andsol;or oxidative stress play a role can be treated by administering an effective amount of an indole3propionic acid or a salt or ester thereof.