METHODS FOR DETECTING AND MODULATING THE SENSITIVITY OF TUMOUR CELLS TO ANTI-MITOTIC AGENTS

摘要

A method of screening a tumour cell for resistance to a tubulin-binding agent, the method comprising detecting the expression of any one or more of class II, class III and class IVb ß-tubulin by the tumour cell, wherein the expression of any one or more of class II, class III and class IVb ß-tubulin indicates that the tumour cell has resistance or potential resistance to the tubulin-binding agent.