INHIBITION OF PLATELET AGGREGATION THROUGH ACYCLOVIR AND TWO PEPTIDE ANTAGONISTS

摘要

A method of inhibiting platelet activation in an human subject comprises the step of treating the subject with an agent which has an effect of preventing or disrupting an association between a nucleotide sensitive chloride channel ICLn and a platelet specific Integrin alphaIIbbeta3. The agent may be an inhibitor of the nucleotide sensitive chloride channel ICLn or a ligand having at least a mM binding affinity for an amino acid sequence KVGFFKR, such as a peptide comprising the sequence AKFEEE or the sequence KVGAAKR.