| 发明名称 |
BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR |
| 摘要 |
<p>The present invention provides benzamide inhibitors of the P2X7 receptor of the formula (I), wherein R<1 >-R<3> are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.</p> |
| 申请公布号 |
WO2004099146(A1) |
申请公布日期 |
2004.11.18 |
| 申请号 |
WO2004IB01525 |
申请日期 |
2004.05.10 |
| 申请人 |
PFIZER PRODUCTS INC.;DOMBROSKI, MARK, ANTHONY;DUPLANTIER, ALLEN, JACOB;SUBRAMANYAM, CHAKRAPANI |
发明人 |
DOMBROSKI, MARK, ANTHONY;DUPLANTIER, ALLEN, JACOB;SUBRAMANYAM, CHAKRAPANI |
| 分类号 |
C07D213/56;C07D231/12;C07D233/54;C07D237/14;C07D249/04;C07D261/08;C07D277/30;C07D403/12;C07D405/06;(IPC1-7):C07D213/54;A61K31/395;C07D237/04;C07D237/08 |
主分类号 |
C07D213/56 |
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