SYNTHETIC PEPTIDE ANALOGS OF ARG-PRO-PRO-GLY-PHE AS SELECTIVE INHIBITORS OF THROMBIN AND THROMBIN ACTIVATION OF PROTEASE ACTIVATED RECEPTORS 1 AND 4

摘要

The invention relates to compounds and methods for inhibiting human platelet aggregation, thrombosis and cell activation mediated by PAR1 and PAR4 using peptide analogs of Arg-Pro-Pro-Gly-Phe that contain one or more amino acid substitutions. The invention also includes screening methods for identifying compounds that inhibit thrombin mediated activities.