Methods and compositions for reducing amyloid beta levels

摘要

The present invention provides methods for reducing the level of amyloid beta protein in a cell or tissue, the methods generally involving contacting the cell or tissue with an agent that reduces cystatin C levels and/or activity. The present invention provides methods for treating Alzheimer's disease (AD), and methods for treating cerebral angiopathy, in an individual, the methods generally involving administering to an individual having AD a therapeutically effective amount of an agent that reduces cystatin C levels and/or activity. The present invention further provides methods for identifying an agent that reduces cystatin C levels and/or activity.

主权项

1. A method of reducing the level of human amyloid beta protein in a cell or a tissue, the method comprising contacting the cell or tissue with an antibody that selectively reduces cystatin C levels and/or activity in the cell or tissue, wherein reduction of cystatin C levels and/or activity results in a reduced level of human amyloid beta protein in the cell or tissue.