ANTIARRHYTHMIC AND CARDIOPROTECTIVE SUBSTITUTED -1(2H)ISOQUINOLINES, PROCESS FOR THEIR PRODUCTION, MEDICAMENT CONTAINING THEM AND THEIR USE FOR THE PRODUCTION OF A MEDICAMENT FOR COMBATING HEART FAILURES

摘要

Antiarrhythmic and Cardioprotective Substituted -1(2H)Isoquinolines, proce ss for their production, medicament containing them and their use for the production of a medicament for combating heart failures Described are guanidinocarbonyl isoquinolines I, (see formula I) with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G (see formula VII) X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide , (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their preparation, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmi c conditions as well as cardioprotective agents in mammals.