Nucleic acid molecules encoding 10-deacetylbaccatin III-O-acetyl transferase and related products

摘要

Transacylase enzymes of Taxus cuspidata and the use of such enzymes to produce Taxol(TM), related taxoids, as well as intermediates in the Taxol(TM) biosynthetic pathway are disclosed. Examples of specific enzymes described herein include taxadienol 5-O-acetyl transacylase (TAX1) and 10-deacetylbaccatin III-10-O-acetyl transferase (TAX6). Also disclosed are nucleic acid sequences encoding the T. cuspidata transacylase enzymes.