发明名称 |
ANILIN-DERIVATE ALS STICKSTOFFMONOXID SYNTHASE- INHIBITOREN |
摘要 |
Compounds represented by the general formula (1): <CHEM> (where R1 is SR6 or NR7R8, where R6 is typically an alkyl group having 1 - 6 carbon atoms, R7 is a hydrogen atom, an alkyl group having 1 - 6 carbon atoms or a nitro group, and R8 is a hydrogen atom or an alkyl group having 1 - 6 carbon atoms; R2 and R3 are each typically a hydrogen atom or an alkyl group having 1 - 6 carbon atoms; R4 is a hydrogen atom, an alkyl group having 1 - 6 carbon atoms or an amidino group of which the amine portion may be substituted by an alkyl or nitro group; R5 is a hydrogen atom or an alkyl group having 1 - 6 carbon atoms; Y1, Y2, Y3 and Y4 which may be the same or different are each typically a hydrogen atom, a halogen atom or an alkoxy group having 1 - 6 carbon atoms; n and m are each an integer of 0 or 1), or possible stereoisomers or optically active forms of the compounds or pharmaceutically acceptable salts thereof. The compounds possess a potent nitric oxide synthase inhibiting activity and are useful as therapeutics of cerebrovascular diseases. |
申请公布号 |
AT281430(T) |
申请公布日期 |
2004.11.15 |
申请号 |
AT19950939418T |
申请日期 |
1995.12.12 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
HONDA, TOSHIO;MAKINO, TOSHIHIKO;NAGAFUJI, TOSHIAKI;KITOH, YASUSHI CHUGAI SEIYAKU;KIMURA, NOBUAKI |
分类号 |
C07D295/12;A61K31/155;A61K31/195;A61K31/21;A61K31/215;A61K31/27;A61K31/275;A61K31/40;A61P3/00;A61P3/14;A61P9/00;A61P43/00;C07C57/30;C07C205/11;C07C205/12;C07C205/19;C07C205/37;C07C205/56;C07C211/52;C07C211/53;C07C271/10;C07C279/18;C07C279/30;C07C279/34;C07C279/36;C07C335/16;C07C335/20;C07C335/22;C07C335/32;C07C335/36;C07C381/14;C07D209/48;C07D295/135 |
主分类号 |
C07D295/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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