发明名称 |
THAP proteins as nuclear receptors for chemokines and roles in transcriptional regulation, cell proliferation and cell differentiation |
摘要 |
The invention relates to genes and proteins of the THAP family comprising a THAP domain, and their use in diagnostics, treatment of disease, and in the identification of molecules for the treatment of disease. The invention also relates to uses of THAP-type chemokine-binding agents, such as THAP-family proteins, as a nuclear receptors for a chemokines and to methods for the modulation (stimulation or inhibition) of transcription, cell proliferation and cell differentiation as well as methods for identifying for compounds which modulate THAP-chemokine interactions.
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申请公布号 |
US2004224408(A1) |
申请公布日期 |
2004.11.11 |
申请号 |
US20030733878 |
申请日期 |
2003.12.10 |
申请人 |
GIRARD JEAN-PHILIPPE;AMALRIC FRANCOIS;ROUSSIGNE MYRIAM;CLOUAIRE THOMAS |
发明人 |
GIRARD JEAN-PHILIPPE;AMALRIC FRANCOIS;ROUSSIGNE MYRIAM;CLOUAIRE THOMAS |
分类号 |
C07K14/47;(IPC1-7):A61K48/00;C12N15/85 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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地址 |
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