METHOD FOR THE DETERMINATION OF ABSOLUTE CONFIGURATION OF CHIRAL COMPOUNDS

摘要

A method by which the absolute configuration of chiral compounds such as diamines or amino alcohols can be easily determined at high sensitivity with high precision, more specifically, a method for the determination of absolute configuration of chiral compounds which comprises subjecting a sample solution containing a porphyrin dimer and a chiral compound to circular dichroism spectrophotometric analysis and determining the absolute configuration of asymmetric carbon of the chiral compound on the basis of the sign of the Cotton effect, characterized in that the porphyrin dimer is one satisfying the requirements (a) to (c): (a) the porphyrin dimer is one bridged by a carbon chain, (b) one of the porphyrin rings has a metal center and the other is in the free form, and (c) in the above free-form porphyrin ring, at least either of the second carbon atoms from the carbon atom to which the bridge carbon chain is bonded along the periphery of the porphyrin ring is substituted with methyl or a more bulky group and that the chiral compound is one satisfying the requirements (i) and (ii): (i) the chiral compound is one capable of coordinating to the porphyrin dimer, and (ii) the group capable of coordinating to the porphyrin dimer and the asymmetric carbon atom are bonded directly to each other, or one carbon atom is present between the group capable of coordinating to the porphorin dimer and the asymmetric carbon atom.