发明名称 |
REDUCTION OF THE HOOK EFFECT IN ASSAY DEVICES |
摘要 |
A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes conjugate d probes that contain a specific binding member for the analyte of interest. T he specific binding member preferentially complexes with the analyte within a test sample when contacted therewith. Excess analyte that remains uncomplexe d with the specific binding member undergoes non-specific binding, such as to a hydrophobic domain. As a result, the ability of the uncomplexed analyte to compete with the complexed analyte at the detection zone of the device is restricted. Thus, the incidence of "false negatives" is limited in a simple, efficient, and relatively inexpensive manner.
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申请公布号 |
CA2513895(A1) |
申请公布日期 |
2004.11.04 |
申请号 |
CA20042513895 |
申请日期 |
2004.03.03 |
申请人 |
KIMBERLY-CLARK WORLDWIDE, INC. |
发明人 |
HUANG, YANBIN;WEI, NING;YANG, KAIYUAN |
分类号 |
G01N33/543;G01N33/558;G01N33/58;(IPC1-7):G01N33/58 |
主分类号 |
G01N33/543 |
代理机构 |
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地址 |
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