Biopolymer array fabrication using different drop deposition heads

摘要

A method of fabricating an array of biopolymer probes bound to a surface of a substrate at feature locations. The method uses multiple deposition heads each with a set of nozzles through which drops are dispensed. Drops are deposited during a same cycle onto the feature location from a set of the deposition heads while spaced from the surface. At least some of those drops contain probe precursors, so that the probe precursors bind to the surface through a linker. This depositing is repeated multiple times with the probe precursor deposited in a prior cycle serving as the linker for a probe precursor deposited in a subsequent cycle. Additionally, drops are deposited at a same feature from the set of heads during a one cycle, and further drops are deposited at the same feature from the set of heads during another cycle. Apparatus and computer program products are also provided.