Preparation of composition for treatment or prevention of microbial infections, e.g. bacterial, fungal, protozoal or viral, comprises use of agonist ligand of peroxisome proliferator receptor gamma

摘要

Preparation of a composition (A) for preventing or curing diseases caused by a microorganism (B) that has, on the outer surface of the cell wall, motifs that interact, in a ligand-receptor fashion, with the mannose receptors of macrophages (MMR). The preparation uses at least one agonist ligand (I) for the nuclear receptor PPARgamma (peroxisome proliferator receptor gamma ). Independent claims are also included for the following: (1) method for extracorporeal treatment of a medium containing macrophages by adding (I) so as to induce and/or amplify expression of MMR; and (2) method for extracorporeal inhibition of proliferation of (B) by adding (I) to a medium infected by (B). ACTIVITY : Antibacterial; Fungicide; Protozoacide; Virucide; Anti-HIV; Immunostimulant. MECHANISM OF ACTION : Macrophage Stimulant. Immunodeficient mice (RAG-2) were treated daily (days 1-6) with 0.01 Micromole of 15d-PGJ2 by intraperitoneal injection and on day 2 infected with 10 7>colony-forming units of Candida albicansby oral gavage. Macrophages were recovered by washing the peritoneal cavity, cultured and tested for phagocytosis of C. albicansby measuring incorporation of tritiated uracil into fungal RNA. The mean index of phagocytosis was 76.32%; compared to 59.82% for animals not treated with 15d-PGJ2.