OPTICALLY ACTIVE 2-ALLYLCARBOXYLIC ACID DERIVATIVE AND PROCESS FOR PRODUCING THE SAME

摘要

A process by which an optically active 2-allylcarboxylic acid derivative which is useful as an intermediate for medicines can be easily and industrially produced from a material available at low cost; and a 2-allylcarboxamide derivative which is a novel important intermediate therefor. An N-allylcarboxamide derivative is reacted with a base by diastereoselective rearrangement to obtain a 2-allylcarboxamide derivative. This derivative is converted to a carbamate and solvolyzed to obtain an optically active 2-allylcarboxylic ester. This ester is stereoselectively hydrolyzed with an enzyme to produce a 2-allylcarboxylic acid having a high optical purity. The 2-allylcarboxamide derivative compound is a novel intermediate in the production process.