| 发明名称 |
Congenic rats containing a mutant GPR10 gene |
| 摘要 |
Congenic rats are disclosed which express a truncated form of GPR10, wherein the truncation is the first 64 amino acids present in the NH2-terminus of wild-type GPR10. Also disclosed are in vitro screening methods for identifying compounds that bind to or modulate the function or expression of the truncated GPR10, and thus are useful in treating psychiatric diseases, such as depression and anxiety.
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| 申请公布号 |
US2004216177(A1) |
申请公布日期 |
2004.10.28 |
| 申请号 |
US20040787098 |
申请日期 |
2004.02.27 |
| 申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
JORDAN SHAUN;WATANABE AKIHITO;OKUNO SHIRO;WATANABE TAKESHI |
| 分类号 |
A01K67/027;C07K14/47;C07K14/72;C12N5/10;C12N15/09;C12N15/85;C12Q1/02;G01N33/15;G01N33/50;(IPC1-7):A01K67/027;C07H21/04;C12N5/06 |
主分类号 |
A01K67/027 |
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